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KMID : 0351619720130010001
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Kyungpook Medical Journal
1972 Volume.13 No. 1 p.1 ~ p.12
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Electron Microscopic and Cytochemical Study of Granules of Polymorphonuclear Leukocyte
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Abstract
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It is evident that neutrophils participate in an important-role in body defense mechanisms. The neutrophilic granules -lysosone- are thought as main machinery in the process of digestion cf phagocytized foreign materials. The polymorphonuclear leukocyte granules were investigated by examining developing granulocyte from n:;rmal rabbit bone marrow, in order to study how they exist, from where they are derived a;:.d how they develop. in additcn, acid phospho=_phatase activit}> was scored at electron microscpic level.
The results were:
Two distinct types of granules, azurophil a::d specific, were distinguished on the basis oftheir differences in size, density and time of origin. Both ypes originated from Golgi complex, but azurophil granules originated in the prcgranuloyte stage and specific granules originated in the myelocyte stage. Ko transforming features were found between the two types but azurophil granules decreased in number throughout successive maturation stages. Azurophil granules were more dense and larger than specific granules.
Acid phosphatase activity was found in both immature azurophil and specific granules, as well as cisternae of rEr and Golgi complex, but mature azurophil and ,specific granules did not eZhibit This activity.
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KEYWORD
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